Guaiol

Where it occurs naturally

(-)-Guaiol is reported in many Chinese medicinal plants. Sources: (-)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC

Aroma & flavour

Evidence for a distinct sensory aroma profile for guaiol is not established.

What has research actually studied?

An in-vitro study of isolated (-)-guaiol in non-small-cell lung cancer cells measured mTOR signaling, autophagy markers, cell survival and colony formation. It reported reduced mTORC1/2 signaling and cell proliferation, with results consistent with autophagic cell death. Sources: (-)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC

What the evidence does not show

This is cell-culture research on one enantiomer, not a clinical trial. It does not show that guaiol treats cancer or that the same response occurs in people.

What does its presence in cannabis mean?

No direct human research on cannabis products containing guaiol was identified. Presence in a product does not establish an effect or allow a predictable experience to be inferred.